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Lyme borreliosis (LB) is endemic in many European countries. The prospective, epidemiological Burden of Lyme Disease (BOLD) study used unified case definitions to characterise LB burden in Europe. A retrospective case–control study was nested within the BOLD study to better understand LB risk factors. LB patients were evaluated at 14 healthcare practices in high-LB-incidence areas in six European countries: the…

Abstract Background Loss of, or unwanted changes in employment reduces economic wellbeing and is associated with lower quality of life. People living with chronic breathlessness are less likely to participate in the workforce. The influence of breathlessness on change in employment status is unknown. This study investigates associations between self-reported breathlessness limiting exertion (hereafter breathlessness ) and changes in employment…

Abstract Breathlessness is a common symptom in clinical practice, yet evidence for cost-effective strategies to diagnose the underlying health conditions causing breathlessness remains limited. Using Swedish population data with individuals with moderate to severe breathlessness, we developed an artificial intelligence (AI) reinforcement learning model to identify optimal, low-cost diagnostic pathways for breathlessness tailored to subgroups based on sex and smoking…

Up to 10% of patients with Lyme borreliosis (LB) will experience symptoms that fulfill the Infectious Disease Society of America (IDSA) criteria of post-treatment Lyme disease syndrome (PTLDS). This study assesses PTLDS in the Burden of Lyme Disease (BOLD) study through clinical assessment (“PTLDS Assessed by Clinicians”) and by post hoc evaluation of patient-reported outcomes, including the 36-Item Short Form…

Background Previous research has shown that mobile health (mHealth) interventions are effective in reminding older adults with chronic conditions about health care appointments and promoting adherence to medication schedules. However, the evidence is limited by the short duration and poor quality of the interventions. Objective We evaluated the effectiveness of the Support, Monitoring and Reminder Technology for Mild Dementia (SMART4MD)…

Lyme borreliosis (LB) can manifest as a localized infection or, if left untreated, disseminated disease. This analysis used Patient-Reported Outcome tools to assess general health, fatigue, pain, and cognitive function in patients with localized or disseminated LB, compared with age- and site-matched controls without LB. All participants were enrolled in the Burden of Lyme Disease (BOLD) study; LB cases were…

Contexte: L’essoufflement est fréquent, anxiogène et souvent difficile à préciser en soins primaires. Lorsqu’il persiste au-delà de quatre semaines, il altèrefortement la qualité de vie, la capacité fonctionnelle et le pronostic, et peut conduire à des consultations en urgence si les causes sous-jacentes ne sont pasidentifiées et prises en charge. L’essoufflement chronique est généralement multifactoriel, associant causes cardio-respiratoires et facteurs…