Abstract Background: Chronic obstructive pulmonary disease (COPD) is a severe condition affectingmillions worldwide, leading to numerous annual deaths. The absence of significant symptomsin its early stages promotes high underdiagnosis rates for the affected people. Besidespulmonary function failure, another harmful problem of COPD is the systemic effects,e.g., heart failure or voice distortion. However, the systemic effects […]
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