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Blood biomarkers for Alzheimer’s disease: Reliable change and impacts of renal and blood–brain barrier function

Abstract Introduction Blood-based biomarkers for Alzheimer’s disease (AD) have the potential to improve diagnostic accessibility, but their clinical interpretation requires understanding of variability and biological influences. Methods We repeatedly sampled blood from 57 adults referred for lumbar puncture as part of a cognitive evaluation at a memory clinic. We measured serum phosphorylated- tau-181 (s-p-tau181) and […]

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